Invasive plants are a global problem and require significant funding to manage. Phragmites australis (hereafter Phragmites) is a high priority for resource managers as it continues to invade wetland habitats, creating dense stands that impair wetland functions, reduce property values, and limit recreational area access. A growing body of literature indicates that microbes (e.g., fungi, bacteria) and their symbiotic relationships with plants contribute to invasions. Evidence suggests that microbial interactions benefit Phragmites by enhancing nutrient processing and tolerance to disturbance. However, many aspects of plant-microbe interactions and the roles they play in invasion remain unclear. This presentation summarizes the efforts of the Collaborative for Microbial Symbiosis and Phragmites Management to promote the study of plant-microbe interactions and the development of microbial-based control strategies for Phragmites and other invasives. This presentation also outlines several research questions and an agenda for future work on applied techniques and technologies that reduce Phragmites competitiveness.