Even the best prevention efforts are unable to stop all invasive species introductions, but a program that responds prudently and engages key stakeholders will help minimize the threat of invasions negatively affecting ecosystems. Under several Great Lakes Restoration Initiative grants we implemented a statewide invasive species response program focusing on high threat aquatic plants. We conducted outreach, surveyed reported occurrences, planned and implemented responses for confirmed infestations, monitored results and delivered education programs. These efforts coincided with the revision and implementation of the Michigan AIS State Management Plan, led by the Michigan Department of Environmental Quality. Through this work, we expanded our collaboration with additional partners, including the Midwest Invasive Species Information Network (MISIN) and Cooperative Invasive Species Management Areas (CISMAs). We will discuss the results of our work, and how it can inform future EDR efforts.