Food, energy and water systems are interdependent and rely on natural, social and built components for their safety, security, productivity and resilience. Integrative solutions that minimize energy and water footprints while maximizing healthy food outputs are essential for global sustainability. Post-industrial urban areas face unique legacy challenges for food, energy and water sustainability due to historical and ongoing soil, water and air contamination; social, economic and land use instability; outdated and deteriorating infrastructure; and entrenched conventional food systems. Despite these challenges, advances in research, technology, policy, community action, and education are contributing to a more sustainable food, energy and water future for transitioning urban landscapes. Examples include urban agriculture, green and blue infrastructure, water and waste stream capture and re-use, and creation of the social infrastructure for change. What synergies exist between native ecosystem restoration and urban food-energy-water sustainability? What lessons from urban initiatives can inform sustainability in other landscapes? What new information and research could serve both food-energy-water sustainability and native ecosystems? This panel discussion will address these and other questions that bridge urban-suburban-rural-wilderness gaps for food-energy-water sustainability.